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[Urinary concentration capacity in neonatal hydronephrosis]

G Orejas Rodríguez-Arango1, S García Vicente, C Rey Galán

  • 1Sección de Nefrología Pediátrica, Hospital Central de Asturias, Facultad de Medicina, Oviedo.

Anales Espanoles De Pediatria
|January 1, 1993
PubMed
Summary

Neonatal hydronephrosis impairs renal concentration capacity, as shown by lower than standard responses to desmopressin (DDAVP) in infants. This study found no adverse effects from the DDAVP test in newborns with hydronephrosis.

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Area of Science:

  • Pediatric Nephrology
  • Neonatal Physiology

Context:

  • Neonatal hydronephrosis is a common congenital condition.
  • Assessing renal function in neonates with hydronephrosis is crucial for management.
  • The renal concentrating ability is a key indicator of kidney function.

Purpose:

  • To evaluate the renal concentration capacity in infants diagnosed with neonatal hydronephrosis.
  • To determine if desmopressin (DDAVP) administration can assess renal function in this population.
  • To establish normative data for renal concentration in neonatal hydronephrosis.

Summary:

  • 18 infants with hydronephrosis received intranasal desmopressin (DDAVP).
  • Fluid intake was restricted before and after DDAVP administration.
  • Maximal urine osmolality was significantly lower than expected in both younger (<21 days) and older (22-50 days) neonates, indicating impaired renal concentration capacity.

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Impact:

  • The findings suggest that neonatal hydronephrosis affects the kidney's ability to concentrate urine.
  • The desmopressin (DDAVP) test appears safe for use in neonates with hydronephrosis.
  • This research provides valuable insights for monitoring and managing infants with congenital kidney abnormalities.