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[Neurologic evolution of premature infants following assisted ventilation, with and without bronchopulmonary
J M Vilanova Juanola1, J Figueras Aloy, J Molina González
1Servicio de Neonatología, Hospital Clínico, Facultad de Medicina, Barcelona.
Insights
Bronchopulmonary dysplasia (BPD) in preterm infants requiring ventilation is linked to mild cognitive deficits. However, other neonatal complications, not BPD itself, appear to be the primary drivers of poor neurological outcomes.
Area of Science:
- Neonatalogy
- Pediatric Neurology
- Respiratory Medicine
Abstract:
The aim of this work was to evaluate the influence of bronchopulmonary dysplasia on the neurological outcome of the preterm infant requiring assisted ventilation. Thirty-nine preterm infants requiring ventilation support during 72 hours or more were classified into two groups according to the presence or absence of bronchopulmonary dysplasia (BPD). In the BPD group (n = 11), only the incidence of mild cognitive deficits was significantly higher (36.4 % vs 0 %). Our results suggest that the neurological outcome of the infants with BPD is more closely associated with other neonatal events (intraventricular hemorrhage, periventricular leukomalacia, neonatal seizures, longer ventilation support, maximum serum bilirubin levels, low Apgar score at 10 minutes and poor intake of amino acids) than with the presence of BPD. The data of this study suggest that indomethacin reduces the risk of neurological deficits.