Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Scatter factor and cell motility]

N Kitamura1

  • 1Dept. of Molecular Genetics, Kansai Medical University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Tumor cell invasion involves dispersion and motility, potentially driven by scatter factor (SF) and its receptor, c-met. Understanding these molecular mechanisms is key to targeting cancer cell invasion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Vascular anastomoses in free jejunal reconstruction to the neck vessels: an experience of consecutive 20 cases without using surgical microscope].

Kyobu geka. The Japanese journal of thoracic surgery·2000
Same author

Involvement of hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells.

Biochemical and biophysical research communications·2000
Same author

[Mechanical birth injury].

Ryoikibetsu shokogun shirizu·2000
Same author

Effects of pimobendan, a new cardiotonic agent, on contractile responses in single skeletal muscle fibres of the frog.

Fundamental & clinical pharmacology·2000
Same author

Chemotherapy-induced apoptosis of lymphocytes in esophageal cancer worsens outcome.

Hepato-gastroenterology·2000
Same author

Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.

The Journal of biological chemistry·2000
Same journal

[A Case of Pulmonary Epithelioid Hemangioendothelioma Associated with Multiple Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Long-Term Survival in Three Cases with Pulmonary Metastases from Colorectal Cancer Given Low-Dose S-1 Under a Regimen Combining a Carbohydrate-Restricted Ketogenic Diet, Metformin, Vitamin D, Eicosapentaenoic Acid, and Other Complementary Therapies].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Preventive Effect of Saline Eye Wash for Eye Symptoms Due to High-Dose and Intermediate-Dose Cytarabine Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Examination of Factors Affecting the Efficacy of Naldemedine Tosilate Tablets for Opioid-Induced Constipation].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[Recent Advances in the Treatment of HER2-Altered Solid Tumors].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same journal

[BRAF-Mutant Solid Tumor].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
See all related articles

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cell dispersion and motility are critical for tumor cell invasion.
  • The molecular underpinnings of tumor cell dispersion and motility remain largely unknown.
  • Scatter factor (SF), a protein produced by mesenchymal cells, induces epithelial cell dissociation and migration.

Purpose of the Study:

  • To investigate the role of scatter factor (SF) and its receptor, the c-met proto-oncogene product, in tumor cell invasion.
  • To elucidate the molecular mechanisms by which SF enhances tumor cell motility and invasiveness.
  • To explore potential pathways for increased tumor cell motility via SF signaling.

Main Methods:

  • Review of existing literature on scatter factor (SF) and hepatocyte growth factor (HGF).

Related Experiment Videos

  • Identification of the c-met proto-oncogene product as the receptor for SF.
  • Postulation of three potential mechanisms for SF-mediated tumor cell invasion.

    • Main Results:

    • SF, now identified as hepatocyte growth factor (HGF), promotes the invasiveness of carcinoma cell lines into collagen matrices.
    • The c-met proto-oncogene product acts as the specific receptor for SF/HGF.
    • Three hypothetical mechanisms involving autocrine, paracrine, and altered receptor expression pathways for SF-mediated invasion were proposed.

    Conclusions:

    • SF/HGF signaling through the c-met receptor is implicated in tumor cell invasion.
    • Further studies are needed to validate these proposed mechanisms and their contribution to cancer progression.
    • Targeting the SF/HGF-c-met pathway may offer therapeutic strategies against invasive tumors.