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Early evening nizatidine intake with a meal optimizes the antisecretory effect
P Duroux1, C Emde, P Bauerfeind
1Centre Hospitalier Universitaire Vaudois, Division of Gastroenterology, Lausanne, Switzerland.
Alimentary Pharmacology & Therapeutics
|February 1, 1993
Summary
Taking nizatidine with an early evening meal significantly enhances its acid-reducing effects compared to other meal timings. Optimal anti-secretory effect is achieved when nizatidine is consumed with food, ideally in the early evening.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Nizatidine is a histamine H2-receptor antagonist used to reduce gastric acid secretion.
- The optimal timing for nizatidine administration relative to meals for maximal efficacy is not well-established.
Purpose of the Study:
- To investigate the impact of meal timing on the efficacy of nizatidine.
- To determine the optimal dosing strategy for nizatidine to maximize its anti-secretory effect.
Main Methods:
- A six-armed, double-blind, placebo-controlled trial involving 11 healthy volunteers.
- Gastric pH-metry and plasma nizatidine concentration measurements were conducted.
- Participants received early or late suppers with placebo, early, or late nizatidine (300 mg).
Main Results:
- Early nizatidine administration with an early supper resulted in significantly higher median 21-hour gastric pH (2.50) compared to other regimens.
- Late nizatidine with late supper yielded a median pH of 2.30, while early nizatidine with late supper showed a median pH of 1.90.
- Food intake delayed nizatidine absorption but did not affect its overall bioavailability.
Conclusions:
- Concomitant food intake enhances the anti-secretory effect of nizatidine.
- For optimal efficacy, oral nizatidine should be taken with food, preferably in the early evening.