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Related Experiment Videos

Wearable artificial kidneys for continuous dialysis. A personal view

M Roberts1

  • 1Nephrology Department, Sepulveda Veterans Administration Medical Center, CA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 1, 1993
PubMed
Summary

Researchers developed a wearable artificial kidney using peritoneal dialysis, overcoming protein-related issues in spent fluid. This innovation offers patients greater lifestyle freedom and stable chemistries without blood-related complications.

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Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Continuous dialysis aims to improve patient lifestyle and treatment stability.
  • Previous wearable artificial kidney designs faced challenges like hemofilter clotting and bleeding risks.
  • Continuous ambulatory peritoneal dialysis (CAPD) is wearable but burdened by frequent bag changes, leading to technique failure.

Purpose of the Study:

  • To develop a viable wearable artificial kidney system.
  • To address and overcome the limitations of existing wearable dialysis technologies.
  • To enable a more normal lifestyle for dialysis patients.

Main Methods:

  • Investigated hemofiltration-based wearable kidneys, noting limitations.
  • Explored peritoneal dialysis as an alternative to eliminate blood-related issues.

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  • Developed a method to remove protein from spent CAPD fluid via hemofiltration prior to regeneration.

    • Main Results:

    • Hemofiltration-based kidneys showed hemofilter clotting within 5 days and bleeding risks.
    • Continuous ambulatory peritoneal dialysis (CAPD) is effective but inconvenient due to bag changes.
    • Protein removal through hemofiltration successfully enabled regeneration of peritoneal dialysis fluid.

    Conclusions:

    • A wearable artificial kidney using peritoneal dialysis with pre-filtration is viable.
    • This approach eliminates blood-related complications and improves patient convenience.
    • The developed system offers a promising solution for continuous dialysis therapy.