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Familial melanoma

J A Newton1

  • 1Skin Tumour Laboratory, Royal London Hospital, Whitechapel, UK.

Clinical and Experimental Dermatology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Atypical mole syndrome involves numerous unusual moles, increasing melanoma risk, especially with family history. Diagnosis is clinical, assessing mole characteristics and family history for accurate risk assessment.

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Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Background:

  • Atypical mole syndrome is characterized by numerous moles with abnormal appearance and distribution.
  • This condition can be sporadic or inherited in an autosomal-dominant pattern.
  • It signifies an elevated risk for developing melanoma.

Purpose of the Study:

  • To review the diagnostic criteria and risk assessment for atypical mole syndrome.
  • To emphasize the clinical diagnosis and the importance of family history.
  • To differentiate atypical mole syndrome from sporadic dysplastic nevi.

Main Methods:

  • Clinical assessment of mole count, distribution, and appearance.
  • Evaluation of patient history for personal and family history of moles and melanoma.

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  • Consideration of associated phenotypic features like iris freckles.

    • Main Results:

    • The diagnosis relies on a comprehensive clinical evaluation.
    • Family history significantly influences melanoma risk assessment.
    • Kraemer et al.'s classification aids in risk stratification but requires further validation.

    Conclusions:

    • Atypical mole syndrome diagnosis is primarily clinical, integrating mole characteristics and family history.
    • Individuals with this syndrome require vigilant monitoring for melanoma.
    • Distinguishing atypical mole syndrome from isolated dysplastic nevi is crucial for appropriate management.