Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isotretinoin-associated pseudoporphyria

C A Riordan1, A Anstey, F Wojnarowska

  • 1Department of Dermatology, Wycombe General Hospital, High Wycombe, Bucks, UK.

Clinical and Experimental Dermatology
|January 1, 1993
PubMed
Summary

Two patients developed pseudoporphyria while taking isotretinoin (Roaccutane). Stopping isotretinoin improved their skin condition, suggesting a potential drug interaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Our judgement is influenced by conflict of interest.

The British journal of dermatology·2018
Same author

BJD research letters: concise, thought provoking and of general interest.

The British journal of dermatology·2018
Same author

At its best, peer review is wonderful to behold.

The British journal of dermatology·2018
Same author

The need for longer time horizons for cost-utility evaluation in bullous pemphigoid: reply from the authors.

The British journal of dermatology·2017
Same author

Doxycycline compared with prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial.

The British journal of dermatology·2017
Same author

Updated evidence-based (S2e) European Dermatology Forum guideline on topical corticosteroids in pregnancy.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Isotretinoin (Roaccutane) is a common acne treatment.
  • Pseudoporphyria is a rare skin condition with blistering and photosensitivity.

Observation:

  • Two patients on isotretinoin developed pseudoporphyria.
  • These patients were also taking other medications.
  • Cutaneous changes appeared after isotretinoin initiation.

Findings:

  • Isotretinoin use coincided with pseudoporphyria onset in both cases.
  • Discontinuation of isotretinoin led to clinical improvement.
  • Pre-existing medications were long-term, suggesting a role for isotretinoin.

Implications:

  • Isotretinoin may contribute to pseudoporphyria, possibly through drug interactions.
  • Further investigation into isotretinoin's role in pseudoporphyria is warranted.
  • Clinicians should monitor for pseudoporphyria in patients on isotretinoin, especially those on multiple medications.

Related Experiment Videos