Lymphoepithelioma-like carcinoma of the skin

A 70-year-old patient who presented with a mass on the dorsum of his nose of 2 years evolution is reported. Histologically it was formed by dermal nests and cords of atypical epithelial cells surrounded by an intense inflammatory infiltrate composed of lymphocytes and histiocytes of an usual aspect. The lesion was removed, relapsing 2 years later. The ultrastructural and immunohistochemical results are discussed. We compare another six cases of lymphoepithelioma-like carcinoma, reported in the literature. The differential diagnosis with other related conditions is discussed together with its possible adnexal origin.