Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased urine interleukin-1 levels in aging

Z Liao1, J H Tu, C B Small

  • 1Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. 10461.

Gerontology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of acute upper gastrointestinal bleeding using a novel portable endoscope for both military and civilian use: an animal study.

BMJ military health·2025
Same author

Comparative Outcomes and Toxicity in Patients With Esophageal Cancer After Trimodality Therapy With Step-and-Shoot Intensity-Modulated Radiation Therapy Versus Volumetric Modulated Arc Therapy: The MD Anderson Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

[E<sub>2</sub> signaling in myofibers promots macrophage efferocytosis in mouse skeletal muscles with cardiotoxin-induced acute injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2024
Same author

A machine-learning model based on dynamic contrast-enhanced MRI for preoperative differentiation between hepatocellular carcinoma and combined hepatocellular-cholangiocarcinoma.

Clinical radiology·2024
Same author

[Effect of TFF3 on tight junction protein in eosinophilic chronic sinusitis and its related mechanism].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2023
Same author

Pneumonitis After Concurrent Chemoradiation and Immune Checkpoint Inhibition in Patients with Locally Advanced Non-small Cell Lung Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023

Elderly individuals show significantly increased levels of interleukin-1 (IL-1) in their urine. This finding, observed in 85% of subjects, suggests a notable change in immune markers with aging.

Area of Science:

  • Immunology
  • Gerontology

Background:

  • Previous observations indicated elevated thymocyte mitogenic activity in elderly patients' urine.
  • The role of interleukin-1 (IL-1) in this observed activity required verification.

Purpose of the Study:

  • To confirm increased urine IL-1 levels in the elderly.
  • To quantify IL-1 levels in elderly versus young individuals.
  • To investigate the specific form of IL-1 involved.

Main Methods:

  • Urine samples from 33 elderly (83-95 years) and young (23-37 years) subjects were analyzed.
  • Murine thymocyte bioassays (tritiated thymidine incorporation and MTT dye reduction) were used to measure IL-1 activity.
  • Enzyme-linked immunosorbent assay (ELISA) quantified urine IL-1 beta levels.

Related Experiment Videos

Main Results:

  • 85% of elderly subjects exhibited significantly increased urine IL-1.
  • Mean elderly urine IL-1 levels (MTT assay) were 0.88 U/ml, compared to <0.05 U/ml in young controls.
  • Elderly urine IL-1 beta levels (ELISA) were significantly higher (mean 57.4 pg/ml vs. 2.5 pg/ml).
  • Urine IL-2 levels showed no difference between age groups.
  • Urine protein and creatinine levels did not explain the IL-1 increase.

Conclusions:

  • A significant increase in urine IL-1 is a characteristic finding in elderly individuals.
  • The immunologic significance of this elevated IL-1 requires further research.
  • This age-related change in urinary IL-1 warrants continued investigation.