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Sotalol poisoning associated with asystole
F Alderfliegel1, M Leeman, P Demaeyer
1Department of Intensive Care, Erasme University Hospital, Brussels, Belgium.
Intensive Care Medicine
|January 1, 1993
Summary
Sotalol overdose can cause dangerous heart rhythm problems. This case report details a severe overdose managed with advanced interventions, resulting in a full recovery without lasting effects.
Area of Science:
- Pharmacology
- Cardiology
- Toxicology
Background:
- Sotalol, a beta-blocker, is known for its potential to prolong the Q-T interval.
- This prolongation can lead to life-threatening cardiac arrhythmias, including ventricular tachycardia and fibrillation.
Observation:
- A 70-year-old woman intentionally ingested a large dose of sotalol (6.72 g).
- Despite initial treatments like activated charcoal, glucagon, atropine, and isoprenaline, she experienced two episodes of asystole requiring cardiopulmonary resuscitation.
Findings:
- The patient's condition necessitated advanced interventions, including ventricular pacing and dopamine administration.
- Successful management led to the patient's recovery with no neurological or cardiac sequelae.
Implications:
- This case highlights the critical management strategies for severe sotalol overdose.
- Prompt and aggressive medical intervention can prevent long-term complications from sotalol toxicity.