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Panniculitis and fever in children
S J Schuval1, A Frances, E Valderrama
1Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, NY 11042.
The Journal of Pediatrics
|March 1, 1993
Summary
Histopathologic features aid in classifying childhood panniculitis. Cyclosporine proved effective for histiocytic cytophagic panniculitis unresponsive to other treatments.
Area of Science:
- Dermatology
- Pediatric Pathology
Background:
- Panniculitis in children presents with diverse systemic manifestations.
- Accurate classification of panniculitis subtypes is crucial for effective treatment.
Observation:
- Three pediatric cases of panniculitis with systemic symptoms like fever were analyzed.
- Histopathologic examination focused on inflammation patterns, vasculitis, cellular infiltrate, and erythrophagocytosis.
Findings:
- Histopathology was instrumental in categorizing panniculitides, distinguishing between subtypes.
- Subcutaneous polyarteritis nodosa responded well to corticosteroid therapy.
- Histiocytic cytophagic panniculitis showed poor response to conventional treatments but significant improvement with cyclosporine.
Implications:
- Histopathological analysis offers a robust method for classifying pediatric panniculitis.
- Cyclosporine emerges as a promising therapeutic option for refractory histiocytic cytophagic panniculitis.
- This study highlights the importance of tailored treatment strategies based on specific panniculitis subtypes.