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Induction of arthritis in DA rats by incomplete Freund's adjuvant
G W Cannon1, M L Woods, F Clayton
1Salt Lake City Veterans Affairs Medical Center (VAMC), UT.
Objective:
To define the arthritogenic effects of incomplete Freund's adjuvant (ICFA) injections in DA rats.
Methods:
ICFA was injected into DA rats and other inbred rat strains. The severity of arthritis was scored and associated changes in weight recorded.
Results:
After ICFA injection a mild transient symmetric arthritis developed in 15/22 (68%) of the DA rats observed for greater than 4 weeks. Histologic examination of the observed arthritis showed edema and neutrophil infiltrates with some lymphocytes and plasma cells. No arthritis developed in DA rats given normal saline injections nor in Lewis, DA.1N and WF.1N rats given ICFA.
Conclusions:
Injection of DA rats with ICFA alone can produce arthritis.