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[Accidental intoxication with aconitine (author's transl)]

G Nicolas, P H Desjars, J F Godin

    Toxicological European Research. Recherche Europeenne En Toxicologie
    |January 1, 1978
    PubMed
    Summary

    Aconitine poisoning in a young woman caused heart rhythm abnormalities, including multifocal extrasystoles and arrhythmias. These dangerous cardiac effects resolved naturally within two hours.

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    Area of Science:

    • Cardiology
    • Toxicology
    • Pharmacology

    Background:

    • Aconitine is a potent neurotoxin and cardiotoxin found in plants of the Aconitum genus.
    • Cardiac arrhythmias are a known, potentially life-threatening consequence of aconitine poisoning.

    Observation:

    • A young woman experienced multifocal extrasystoles and alternating sinusal rhythm with junctional arrhythmia after ingesting 3 mg of aconitine.
    • The observed cardiac rhythm abnormalities were transient, resolving spontaneously within a two-hour period.

    Findings:

    • The case demonstrates aconitine's ability to induce significant, albeit temporary, cardiac rhythm disturbances.
    • The study highlights the direct impact of aconitine on cardiac electrophysiology, leading to complex arrhythmias.

    Implications:

    • Understanding aconitine's cardiotoxic effects is crucial for emergency medical treatment of poisoning.
    • This case provides valuable clinical data for further research into the physiopathology of aconitine-induced arrhythmias.

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