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Effect of calcium antagonist on renal graft function
P Alivanis1, D Grekas, A Siulis
1First Medical Department, University Hospital AHEPA, Thessaloniki, Greece.
Renal Failure
|January 1, 1993
Summary
Nifedipine administration improved kidney transplant outcomes by enhancing diuresis and reducing acute tubular dysfunction and rejection episodes. This calcium channel blocker shows promise in protecting renal function post-transplantation.
Area of Science:
- Nephrology
- Transplantation Immunology
- Pharmacology
Background:
- Calcium antagonists have demonstrated protective effects against ischemic injury in experimental renal models.
- Kidney transplantation is susceptible to ischemic damage and rejection, necessitating protective strategies.
Purpose of the Study:
- To evaluate the efficacy of nifedipine in protecting renal function and reducing complications after kidney transplantation.
Main Methods:
- A prospective study comparing 35 kidney transplant recipients receiving nifedipine (nifedipine group) with 35 controls.
- Nifedipine was administered intra-arterially post-revascularization and orally throughout the study period.
- Key outcomes included diuresis, acute tubular dysfunction, serum creatinine, fractional sodium excretion, and acute rejection episodes.
Main Results:
- The nifedipine group achieved adequate diuresis significantly faster than the control group (p < 0.01).
- Lower incidence of acute tubular dysfunction and lower mean serum creatinine levels were observed in the nifedipine group.
- A significantly lower rate of acute rejection episodes occurred in the nifedipine group within the first six months (p < 0.05).
Conclusions:
- Nifedipine administration appears effective in preserving renal function following kidney transplantation.
- The drug may mitigate ischemic injury, reduce tubular dysfunction, and decrease the incidence of acute rejection episodes.