Related Experiment Videos
[Disorders of myocardial function in patients with normal coronary angiography]
1Abteilung für Kardiologie und Angiologie, Universität Leipzig.
Insights
Intraventricular contrast media injection during angiocardiography can reveal latent myocardial disease. An increase in left ventricular end-diastolic pressure (LVEDP) post-injection indicates preclinical heart conditions.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Myocardial Function
Context:
- Assessing latent myocardial disease is crucial for early intervention.
- Coronary heart disease (CHD) and angina pectoris present diagnostic challenges.
- Angiocardiography is a key diagnostic tool in cardiovascular assessment.
Purpose:
- To evaluate the utility of intraventricular contrast media injection in diagnosing preclinical myocardial disease.
- To analyze cardiac function parameters, specifically left ventricular end-diastolic pressure (LVEDP), in response to contrast media.
- To correlate changes in LVEDP with the severity of coronary heart disease.
Summary:
- Left ventricular end-diastolic pressure (LVEDP) was measured in 350 patients before and after intraventricular contrast media injection.
- Patients with coronary heart disease showed a significant LVEDP increase post-injection (23.7 mmHg) compared to those with normal coronary arteries (19.2 mmHg).
- The contrast injection acts as a volume stress, revealing preclinical left ventricular myocardial disease through elevated LVEDP.
Impact:
- This method can identify latent myocardial disease not apparent under resting conditions.
- Ventriculography with contrast media provides a valuable non-invasive method for detecting early-stage heart conditions.
- Early detection through this technique may lead to timely therapeutic interventions and improved patient outcomes.
Abstract:
An attempt is made to estimate the value of intraventricular injection of contrast media in the procedure of angiocardiography for registration of a latent disease of the myocardium. For this purpose the parameter of the cardial function of 350 patients are analysed depending on the severity of the coronary heart disease. Under resting conditions the left ventricular end-diastolic pressure (LVEDP) of patients with coronary heart disease was 19.9 +/- 7.98 mmHg. The LVEDP of patients with the angina pectoris syndrome but normal epicardial coronary arteries was 15.6 +/- 5.45 mmHg. The LVEDP of the most of the patients rose after injecting contrast medium in the left ventricle independent of the resting level. Patients with coronary heart disease had a LVEDP of 23.7 +/- 9.48 mmHg after injecting the contrast media, while patients with normal coronary arteries had a LVEDP of 19.2 +/- 7.21 mmHg. The left ventricular systolic pressure and the parameters of contractility did not change significantly after injecting contrast media. The injection of contrast medium into the left ventricle--i.e. the ventriculography--is in a qualified sense a volume stress to the left ventricle. That means an increase of a normal LVEDP after an injection of contrast medium uncovers a preclinical disease of the left ventricular myocardium.