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Updated: Aug 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Ischemic cerebrovascular accidents in homozygous sickle cell anemia. Two case reports]
Insights
Sickle cell anemia can cause ischemic stroke in children. Periodic blood transfusions and bone marrow transplants can prevent strokes and offer a cure for this blood disorder.
Area of Science:
- Pediatric Hematology
- Neurology
- Genetics
Background:
- Sickle cell anemia is a genetic blood disorder.
- Ischemic stroke is a serious complication in children with sickle cell anemia.
- Children of Tunisian descent are affected.
Abstract:
Two cases of ischemic stroke in children of Tunisian descent with sickle cell anemia are reported. Patients were aged 3 years and 14 years, respectively. Periodic partial exchange transfusions with sedimented red blood cells of identical phenotype prevented further episodes of ischemic stroke. Transplantation of HLA-identical bone marrow from a family member offers a chance of complete cure of the hemoglobin disorder in these children who are at risk of recurrent stroke.
Related Concept Videos
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology

