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In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection

M E Scott1, A L Landay, T F Lint

  • 1Department of Pediatrics, Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois 60612.

AIDS (London, England)
|January 1, 1993
PubMed
Summary
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HIV infection significantly reduces complement receptor 2 (CR2) expression on B-cells, potentially explaining B-cell dysfunction and impaired immune responses in patients. This decrease is observed even in early stages of HIV.

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • Complement receptor 2 (CR2) plays a role in B-cell activation.
  • B-cell dysfunction is a known complication of HIV infection.

Purpose of the Study:

  • To investigate changes in CR2 expression on B-cells from individuals with HIV infection.
  • To explore the association between CR2 expression and B-cell dysfunction in HIV.

Main Methods:

  • A cross-sectional study comparing HIV-infected adults with age-matched controls.
  • Flow cytometry was used to measure CR2 expression on CD20+ B-cells, along with CD19, CD69, and HLA-DR.

Main Results:

  • HIV-infected individuals showed a significant decrease in CR2 co-expression on B-cells compared to controls (71% vs. 94%).

Related Experiment Videos

  • The decrease in CR2 expression did not correlate with HIV disease stage or CD4+ T-cell counts.
  • Some patients exhibited reduced CR2 antigen density on their B-cells.

    • Conclusions:

    • Reduced CR2 expression on B-cells in HIV-infected individuals may contribute to observed B-cell dysfunction.
    • The findings suggest early B-cell defects in HIV infection, even in asymptomatic patients.
    • Further research into CR2's role could illuminate increased bacterial infections and impaired vaccine responses in HIV.