Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Internal anal sphincter dysfunction in neurogenic faecal incontinence

R Farouk1, G S Duthie, A Pryde

  • 1Department of Surgery, Royal Infirmary, Edinburgh, UK.

The British Journal of Surgery
|February 1, 1993
PubMed
Summary

Patients with neurogenic faecal incontinence exhibit abnormal internal anal sphincter (IAS) relaxation patterns. These frequent IAS relaxations may lead to involuntary fecal leakage in affected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traditional measures of normal anal sphincter function using high-resolution anorectal manometry (HRAM) in 115 healthy volunteers.

Neurogastroenterology and motility·2014
Same author

Simultaneous dyeing and antibacterial finishing for cotton cellulose using a new reactive dye.

Carbohydrate polymers·2013
Same author

Melanosis coli in the absence of anthranoid laxative use harbouring adenoma.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Temporary gastric neuromodulation for intractable nausea and vomiting.

Annals of the Royal College of Surgeons of England·2011
Same author

Injectable anal bulking agent for the management of faecal incontinence.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2011
Same author

Sacral neuromodulation for the treatment of faecal incontinence in a patient with organophosphate poisoning.

Techniques in coloproctology·2010

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Physiology

Background:

  • Neurogenic faecal incontinence significantly impacts quality of life.
  • Understanding the underlying physiological mechanisms of IAS dysfunction is crucial.

Purpose of the Study:

  • To investigate the anal sphincter function in patients with neurogenic faecal incontinence.
  • To compare IAS electromyography and manometry findings between patients and healthy controls.

Main Methods:

  • Fine-wire anal sphincter electromyography and anal manometry were performed.
  • Median electromyogram frequency, ambulatory resting pressure, and transient IAS relaxation frequency were measured.
  • Mid-anal and rectal pressures during IAS relaxation were analyzed.

Related Experiment Videos

Main Results:

  • Patients showed significantly lower IAS electromyogram frequency and ambulatory resting pressure compared to controls.
  • The frequency of transient IAS relaxations was higher in patients (9/h) than in controls (4/h).
  • Abnormal rectal pressure increases during IAS relaxation were observed in 36 patients, exceeding mid-anal pressure.

Conclusions:

  • Frequent abnormal transient internal anal sphincter relaxations are a key finding in neurogenic faecal incontinence.
  • These aberrant relaxation patterns likely contribute to occult faecal leakage.
  • Definitive IAS dysfunction underlies neurogenic faecal incontinence, necessitating targeted therapeutic strategies.