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Diethylstilbestrol liver carcinogenicity and modification of DNA in rats
G M Williams1, M Iatropoulos, R Cheung
1American Health Foundation, Valhalla, NY 10595.
Cancer Letters
|February 1, 1993
Abstract:
Administration of diethylstilbestrol to female Sprague-Dawley rats at 10 mg/kg body weight daily by gavage for 1 year induced liver adenomas and carcinomas and pituitary adenomas. Using the 32P-postlabeling assay for DNA alterations, at 24 h after administration of a single dose of 100 mg/kg, modified bases were found.