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Related Experiment Videos

Nasal ketamine for paediatric premedication

N Weksler1, L Ovadia, G Muati

  • 1Department of Anaesthesia, Hillel Yaffe Medical Center, Hadera, Israel.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|February 1, 1993
PubMed
Summary
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Nasal ketamine provided superior preanesthetic sedation in children aged two to five years compared to intramuscular promethazine and meperidine. This study suggests nasal ketamine is a viable alternative for pediatric sedation before surgery.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Preanesthetic sedation is crucial for pediatric surgical patients.
  • Intramuscular (IM) injections can be painful and distressing for children.
  • Alternative, less invasive sedation methods are needed.

Purpose of the Study:

  • To evaluate the efficacy of nasal ketamine for preanesthetic sedation in young children.
  • To compare nasal ketamine with traditional IM promethazine and meperidine sedation.

Main Methods:

  • A comparative study involving 86 healthy children (2-5 years) receiving nasal ketamine (6 mg/kg).
  • A control group of 62 children (2-5 years) received IM promethazine and meperidine (1 mg/kg each).
  • Sedation quality and salivation were assessed before elective surgery.

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Main Results:

  • Nasal ketamine resulted in significantly higher rates of excellent or adequate sedation (67/86) compared to the IM group (21/62) (P < 0.05).
  • Salivation levels were comparable between the two groups.
  • Nasal ketamine was administered 20-40 minutes prior to surgery.

Conclusions:

  • Nasal ketamine is an effective and well-tolerated alternative for preanesthetic sedation in children aged 2-5 years.
  • It offers a less invasive option compared to IM injections for pediatric surgical sedation.