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Delayed poststimulus decrease of phrenic motoneuron output produced by phrenic nerve afferent stimulation

J D Road1, S Osborne, Y Wakai

  • 1Department of Medicine, University of British Columbia, Vancouver, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1993
PubMed
Summary
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Stimulating phrenic afferent nerves can prolongedly decrease respiratory motoneuron output. This effect, similar to limb muscle nerve stimulation, suggests a shared inhibitory pathway for respiratory control.

Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • Phrenic afferent nerve activation has immediate excitatory and inhibitory effects on ventilation.
  • Long-lasting inhibitory effects on respiratory motoneuron output are known from limb muscle afferent nerve stimulation.

Purpose of the Study:

  • To investigate if respiratory muscle afferent nerves, specifically phrenic afferent nerves, can produce prolonged decreases in respiratory motoneuron output.
  • To test the hypothesis that phrenic afferent nerve activation leads to a prolonged reduction in respiratory motoneuron output.

Main Methods:

  • Electrical stimulation of the phrenic nerve's proximal end in alpha-chloralose-anesthetized dogs.
  • Recording of contralateral efferent phrenic electroneurogram (ENG) activity during and after stimulation.
  • Controlled ventilation to maintain end-tidal CO2 levels in paralyzed dogs.

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Main Results:

  • Phrenic nerve stimulation initially increased ENG activity.
  • A delayed, prolonged decrease in phrenic ENG activity was observed post-stimulation, reaching a peak reduction of 19%.
  • This inhibitory effect lasted approximately 30 minutes and was qualitatively similar to responses from gastrocnemius nerve stimulation.

Conclusions:

  • Activation of thin-fiber afferents in the phrenic nerve can induce a delayed and prolonged decrease in respiratory motoneuron output.
  • This finding suggests a similarity between the inhibitory effects of respiratory muscle afferent nerves and limb muscle afferent nerves.
  • The study supports a shared neural pathway for prolonged respiratory inhibition.