Related Experiment Videos
Thyroid dysfunction in refractory depression: implications for pathophysiology and treatment
1Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pa. 15213.
The Journal of Clinical Psychiatry
|February 1, 1993
Summary
Subclinical hypothyroidism is significantly linked to refractory depression, suggesting it may be a distinct biological subtype. Future research should measure thyroid and beta-adrenergic function to clarify treatment outcomes.
Area of Science:
- Neuroscience
- Endocrinology
- Psychiatry
Background:
- Refractory depression studies often lack methodological rigor and biological measures.
- Thyroid dysfunction is increasingly recognized as a factor in treatment-resistant depression.
Purpose of the Study:
- To review clinical and preclinical research on thyroid dysfunction in refractory depression.
- To identify the role of hypothyroidism in treatment-resistant depression.
Main Methods:
- Conducted a comprehensive literature search of MEDLINE and bibliographies.
- Included clinical studies of refractory depression with thyroid function measures.
- Reviewed animal models of depression examining antidepressant response factors.
Main Results:
- Subclinical hypothyroidism found in 52% of refractory depression patients, compared to 8-17% in general depressed populations.
- Animal studies suggest hypothyroidism plays a pathophysiological role, potentially via altered beta-adrenergic function.
Conclusions:
- Hypothyroidism is significantly associated with refractory depression, indicating a potential biological subtype.
- Inconsistent treatment augmentation results may stem from inadequate investigation of thyroid and beta-adrenergic function.
- Future research must include these measures to advance understanding and treatment of refractory depression.