Targeted hormone therapy for breast cancer

V C Jordan1

  • 1Breast Cancer Program, University of Wisconsin Comprehensive Cancer Center, Madison.

Hospital Practice (Office Ed.)
|March 15, 1993
PubMed

Insights

Antiestrogen treatments now have clear clinical guidelines. Future research will explore antiestrogen use for breast cancer prevention and novel therapeutic strategies like antiprogestins.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Antiestrogen therapies are established treatments for various patient groups.
  • Current clinical practice benefits from large-scale study guidelines.

Purpose of the Study:

  • To summarize current antiestrogen treatment guidelines.
  • To identify future research directions in breast cancer therapy.

Main Methods:

  • Review of large-scale clinical studies.
  • Analysis of existing treatment guidelines.

Main Results:

  • Clear guidelines exist for antiestrogen therapy in defined patient populations.
  • Significant challenges remain in breast cancer management.

Conclusions:

  • Clinicians have established protocols for antiestrogen use.
  • Future research should focus on prevention, etiology, and novel agents like antiprogestins.

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...