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In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues
A Bogdan1, A Auzéby, P F Plouin
1Biochemical Department, Faculté de Médecine Pitié, Paris, France.
Journal of Endocrinological Investigation
|January 1, 1993
Abstract:
The in vitro metabolism of [1,2-3H] deoxycorticosterone (DOC), [1,2-3H] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-3H] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability.