Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro-in vivo correlation for modified-release formulations

J Drewe1, P Guitard

  • 1Department of Anesthesia, University Hospital, University of Basel/Kantonsspital, Switzerland.

Journal of Pharmaceutical Sciences
|February 1, 1993
PubMed
Summary

This study correlated in vitro dissolution rates with in vivo pharmacokinetics for a sustained-release bromocriptine formulation. Different correlation methods were evaluated to assess their effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Active animal health surveillance in European Union Member States: gaps and opportunities.

Epidemiology and infection·2016
Same author

Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2014
Same author

Neural effects of green tea extract on dorsolateral prefrontal cortex.

European journal of clinical nutrition·2012
Same author

Intranasal midazolam: pharmacokinetics and pharmacodynamics assessed by quantitative EEG in healthy volunteers.

Clinical pharmacology and therapeutics·2012
Same author

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).

Clinical nutrition (Edinburgh, Scotland)·2011
Same author

Safety, tolerability and pharmacokinetics of intravaginal pentamycin.

Chemotherapy·2010

Area of Science:

  • Pharmacokinetics
  • Drug Delivery Systems
  • Pharmaceutical Sciences

Background:

  • Sustained-release formulations aim to control drug release kinetics.
  • Predicting in vivo drug performance from in vitro data is crucial for formulation development.

Purpose of the Study:

  • To establish a correlation between in vitro dissolution rate and in vivo pharmacokinetic parameters for bromocriptine.
  • To compare the outcomes of various methods used for establishing this correlation.

Main Methods:

  • In vitro dissolution testing of a sustained-release bromocriptine formulation.
  • In vivo pharmacokinetic studies in human subjects.
  • Application and comparison of different mathematical models to correlate in vitro and in vivo data.

Related Experiment Videos

Main Results:

  • A correlation was successfully established between specific in vitro dissolution parameters and in vivo pharmacokinetic outcomes.
  • The effectiveness of different correlation methods varied, highlighting the importance of method selection.

Conclusions:

  • In vitro dissolution testing can predict in vivo performance of sustained-release bromocriptine.
  • The choice of correlation methodology significantly impacts the predictive accuracy.