Insomnia in neurological diseases
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Updated: Oct 23, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
1Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109.
Abstract:
Sleep disturbance, common in many neurological diseases, can be caused by underlying CNS pathology, altered motor system function, associated cognitive and psychiatric disorders, secondary effects of the disease such as pain and immobility, and medication effects. Nocturnal behavioral disturbances are a major contributor to institutionalization of such patients, and respiratory abnormalities of sleep can be life-threatening. Rational approach to diagnosis and treatment can lead to significant improvements in many such patients.
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