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Thermal sensitivity in demyelinating neuropathy

V Chaudhry1, T O Crawford, S E DeRossett

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Muscle & Nerve
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Fever can worsen weakness in children with demyelinating peripheral neuropathy. Demyelinated nerves are more vulnerable to temperature changes, impacting nerve impulse conduction.

Area of Science:

  • Neurology
  • Clinical Electrophysiology

Background:

  • Demyelinating peripheral neuropathies affect nerve function.
  • Temperature sensitivity in neurological conditions is a known phenomenon.

Observation:

  • An 8-year-old girl with demyelinating peripheral neuropathy experienced significant weakness during a febrile illness.
  • Her strength returned to baseline as her temperature normalized.

Findings:

  • Experimental cooling and warming of the patient's nerves showed significant reduction in Compound Muscle Action Potential (CMAP) amplitude with increased temperature.
  • Demyelinated nerves demonstrated an 80% reduction in CMAP amplitude at 39.5°C, compared to 48% in control subjects.

Implications:

  • This study provides the first clinical evidence of temperature-induced impulse blocking in demyelinating peripheral neuropathy outside of multiple sclerosis.

Related Experiment Videos

  • Findings suggest that fever management may be crucial for patients with certain demyelinating neuropathies.