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Genetic defects in proteoglycan biosynthesis
E Quentin-Hoffmann1, B Harrach, H Robenek
1Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Federal Republic of Germany.
Abstract:
An overview on the structure of proteoglycans and on genetic defects in proteoglycan biosynthesis is given. Several patients with progeroid-like symptoms have been shown to have abnormalities in the biosynthesis of chondroitin/dermatan sulfate proteoglycans. A partial inactivity of galactosyltransferase I which catalyzes the second glycosyl transfer reaction in the assembly of glycosaminoglycan chains has been shown to represent the primary defect in one of the patients. A diminished concentration of a collagen-associated proteoglycan is considered to play a pathogenetic role in the development of loose skin.