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[Rheumatoid factor IgM analyses in Danish laboratories. An interlaboratory study]

B Schiøttz-Christensen1, M Høier-Madsen, B Langeland

  • 1Klinisk immunologisk afdeling, Aalborg Sygehus.

Ugeskrift for Laeger
|March 1, 1993
PubMed
Summary

This study compared rheumatoid factor IgM analysis across Danish labs. Results showed acceptable correlation for ELISA and nephelometry between 10-200 IU/ml, though nephelometry yielded higher concentrations.

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Area of Science:

  • Clinical Chemistry
  • Immunology

Background:

  • Rheumatoid factor (RF) is a key biomarker in diagnosing rheumatoid arthritis.
  • Standardization of RF assays is crucial for accurate patient diagnosis and monitoring.

Purpose of the Study:

  • To evaluate the inter-laboratory correlation of rheumatoid factor IgM measurements in Denmark.
  • To compare the performance of ELISA and nephelometry techniques for RF analysis.

Main Methods:

  • Rheumatoid factor IgM concentrations were measured in 10 sera samples across 17 Danish laboratories.
  • Thirteen laboratories utilized the ELISA technique, while four employed nephelometry.

Main Results:

  • Acceptable correlation was observed between laboratories using the same technique within the 10 to 200 IU/ml range.

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  • Nephelometry technique resulted in higher RF IgM concentrations compared to the ELISA technique.

    • Conclusions:

    • While intra-technique correlation is acceptable, differences exist between ELISA and nephelometry for RF IgM quantification.
    • Further standardization efforts are needed to harmonize RF testing across different laboratory methods.