Two-Hz wide EEG bands in Alzheimer's disease

Twenty Alzheimer's Disease (AD) patients in a mild to moderate stage of the disease and 20 control subjects were compared in 17 2-Hz wide bands from the electrodes 01, 02, P3, P4, T5, T6, F3, F4, F7, F8, Fp1, and Fp2. Differences reached statistical significance for 0-2 and 4-6 Hz bands, where AD patients presented highest power values. The AD group was divided into two groups according to the stage of disease. Both groups of patients presented 0-2 Hz increase in frontal, right parieto-temporal, and occipital areas. The increase in 4-6 Hz band was mainly over frontal areas in both groups and over left parietal region in moderate AD patients. These results and those relative to dominant frequency and crossover frequency between groups are discussed according to previous results with conventional and 2-Hz wide bands in AD patients in a severe stage of the disease.