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Related Experiment Videos

MR detection of quantitative and structural changes in human aortic aneurysms

P Vinée1, B Meurer, A Constantinesco

  • 1Laboratoire de Biomécanique, CHRU Hautepierre, Strasbourg, France.

Journal of Magnetic Resonance Imaging : JMRI
|March 1, 1993
PubMed
Summary

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Aortic aneurysm degeneration alters collagen structure and molecular motion, impacting the aorta's elastic properties. These changes are linked to increased tension and reduced wall thickness in diseased aortas.

Area of Science:

  • Biophysics
  • Biomaterials Science
  • Cardiovascular Research

Background:

  • Collagen is crucial for aortic elasticity and extracellular matrix integrity.
  • Aneurysmal degeneration involves significant changes in aortic wall composition and mechanical properties.

Purpose of the Study:

  • To investigate structural and molecular motion alterations of collagen in human aortic aneurysms.
  • To correlate these collagen changes with the biomechanical environment of aneurysmal degeneration.

Main Methods:

  • Solid-state hydrogen-1 nuclear magnetic resonance (NMR) line shape analysis.
  • Three-component decomposition of free induction decay to characterize collagen.
  • Measurement of T2 relaxation times and second moment of the collagen line shape.

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Main Results:

  • Collagen exhibited a lower T2 relaxation time (16.3 µs vs. 17.7 µs) and increased line shape second moment (5.3 G² vs. 4.8 G²) in aneurysms.
  • Collagen concentration was found to be lower in non-diseased aortic walls (7.3% vs. 9.4%).
  • These findings indicate modified collagen structure and reduced molecular motion in aneurysmal tissue.

Conclusions:

  • Aneurysmal degeneration leads to significant modifications in collagen structure and molecular dynamics.
  • These collagen alterations are likely adaptive responses to increased mechanical stress (tangential tension) and reduced aortic wall thickness.
  • The observed changes may involve intercalation, site binding within collagen helices, or altered electric dipolar interactions.