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Behavioural correlates of alcohol intoxication

C A Naranjo1, K E Bremner

  • 1Clinical Pharmacology and Pharmacotherapy Research Unit, Addiction Research Foundation, Toronto, Canada.

Addiction (Abingdon, England)
|January 1, 1993
PubMed
Summary

Alcohol abuse causes significant physical, psychological, and social harm, increasing risks for accidents and aggression. Research is exploring medications to counteract alcohol

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Public Health

Background:

  • Alcohol consumption is widespread, despite known risks of physical, psychological, and social problems.
  • Alcohol abuse is linked to impaired driving, aggression, violence, and various accidents, with significant public health implications.
  • Factors influencing behavioral impairment include blood alcohol concentration (BAC), metabolism rates, and individual characteristics.

Purpose of the Study:

  • To review the multifaceted consequences of alcohol abuse and intoxication.
  • To explore the pharmacological and psychosocial factors contributing to alcohol-related harm.
  • To examine potential pharmacotherapies for mitigating alcohol's adverse effects.

Main Methods:

  • Literature review of studies on alcohol's effects on behavior and metabolism.
  • Analysis of epidemiological data on alcohol-related accidents and social consequences.
  • Examination of preclinical and clinical research on potential amethystic agents.

Main Results:

  • Alcohol intoxication significantly increases the risk of fatal traffic accidents, falls, drownings, and fires.
  • Alcohol abuse is associated with aggressive behaviors and work-related accidents, though precise pharmacological links are complex.
  • Alcohol interacts with other drugs, altering their metabolism and effects; research into amethystic agents like Ro15-4513 shows promise but requires further validation.

Conclusions:

  • Alcohol abuse poses substantial risks to individual well-being and public safety.
  • Understanding the interplay of pharmacological and psychosocial factors is crucial for addressing alcohol-related harm.
  • Further research is needed to establish the clinical efficacy of amethystic agents and other pharmacotherapies for alcohol-related issues.

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