Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanced tumor imaging with pokeweed mitogen

D M Bitner1, P L Mann, P D'Souza

  • 1University of New Mexico, Center for Non-Invasive Diagnosis, Albuquerque 87131.

Nuclear Medicine and Biology
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life sciences licensing deals in the second quarter of 2018: updates and trends.

Drugs of today (Barcelona, Spain : 1998)·2018
Same author

The year's new drugs & biologics, 2017, part II - News that shaped the industry in 2017.

Drugs of today (Barcelona, Spain : 1998)·2018
Same author

Life sciences licensing deals in the fourth quarter of 2017: updates and trends.

Drugs of today (Barcelona, Spain : 1998)·2018
Same author

Notable licensing deals in the biopharma industry in the third quarter of 2017.

Drugs of today (Barcelona, Spain : 1998)·2017
Same author

Notable licensing deals in the biopharma industry in the second quarter of 2017.

Drugs of today (Barcelona, Spain : 1998)·2017
Same author

Notable deals in the pharmaceutical industry in the fourth quarter of 2016.

Drugs of today (Barcelona, Spain : 1998)·2017
Same journal

Electroless semi-automatic synthesis of <sup>225</sup>Ac-labeled PSMA-derivatives for clinical application and evaluation of rechelation capability.

Nuclear medicine and biology·2026
Same journal

Preparation of electroplated zinc-68 targets for gallium-68 cyclotron production using recovered zinc-68.

Nuclear medicine and biology·2026
Same journal

Enhanced pre-therapy dosimetry for SSTR PET: A head-to-head preclinical assessment of [<sup>89</sup>Zr]Zr-DFO-TOC and [<sup>89</sup>Zr]Zr-DFO-TATE.

Nuclear medicine and biology·2026
Same journal

Pharmacokinetics and dosimetry of radiolabeled FAP-targeting single-domain antibody 4AH29 in Göttingen minipigs.

Nuclear medicine and biology·2026
Same journal

Comparative intra-articular retention of [<sup>177</sup>Lu]Lu-MAA and <sup>90</sup>Y resin in a rat knee model.

Nuclear medicine and biology·2026
Same journal

Evaluating the tumour detection efficacy of [<sup>18</sup>F]Fluorthanatrace positron emission tomography in a metastatic lung cancer animal model.

Nuclear medicine and biology·2026
See all related articles

This study shows that altering tissue clearance rates with pokeweed mitogen (PWM) can improve tumor imaging. PWM enhances radiotracer tumor visualization and increases tumor-to-muscle ratios for better detection.

Area of Science:

  • Biomedical imaging
  • Radiochemistry
  • Oncology

Background:

  • Traditional tumor imaging relies on biomolecule specificity.
  • Altering radiotracer tissue clearance offers a novel imaging approach.

Purpose of the Study:

  • To investigate if pokeweed mitogen (PWM) can modulate tissue clearance rates for enhanced tumor imaging.
  • To assess PWM's effect on tumor-to-muscle ratios using a non-tumor-specific biomolecule.

Main Methods:

  • In vivo imaging of B-16/C57BL/6 tumors using 99mTc-PWM.
  • Tumor imaging and biodistribution studies with 99mTc-human serum albumin (HSA) in PWM-treated and control groups.
  • Tissue clearance studies using 99mTc-diethylenetriaminepentaacetic acid (DTPA) in mice.

Main Results:

Related Experiment Videos

  • Specific tumor imaging with 99mTc-PWM achieved 120-240 min post-injection.
  • PWM treatment increased tumor-to-muscle ratios by 32-59% with 99mTc-HSA.
  • PWM significantly increased normal tissue clearance rates of 99mTc-DTPA.

Conclusions:

  • Pokeweed mitogen (PWM) effectively modulates tissue clearance rates.
  • PWM enhances tumor visualization and improves imaging contrast.
  • This biomodulation strategy holds promise for improving diagnostic accuracy in tumor imaging.