Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abscess scintigraphy with 99mTc-human immunoglobulin (IgG) using a one-step labeling method

Z H Oster1, P Som, B A Rhodes

  • 1Brookhaven National Laboratory, Medical Department, Upton, New York 11973.

Nuclear Medicine and Biology
|February 1, 1993
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Characteristic and function of peripheral blood mononuclear cells-induced macrophages in patients with myelodysplastic syndrome].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2017
Same author

[Establishment of cut-off value of serum pro-gastrin-releasing peptide for diagnosis of small cell lung cancer and evaluation on the clinical diagnosis efficiency].

Zhonghua yi xue za zhi·2017
Same author

First report of peste des petits ruminants virus lineage II in Hydropotes inermis, China.

Transboundary and emerging diseases·2017
Same author

[The value of B7-H4 and carcinoembryonic antigen in diagnosing the benign and malignant pleural effusion].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2017
Same author

[Study on autophagy in nucleated red blood cells in patients with myelodysplastic syndromes].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2017
Same author

[High resolution diffusion-weighted imaging for characterising nasopharyngeal carcinoma].

Zhonghua yi xue za zhi·2017

Technetium-99m labeled immunoglobulin G (99mTc-IgG) shows promise for abscess detection, offering higher abscess-to-tumor ratios and faster imaging times compared to Indium-111 IgG. This radiotracer presents advantages in preparation, cost, and dose flexibility.

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Imaging
  • Biomedical Research

Background:

  • Non-specific human immunoglobulin G (IgG) labeled with Indium-111 (111In-IgG) has been previously established for abscess localization.
  • The development of novel radiotracers is crucial for improving diagnostic accuracy in infectious and neoplastic diseases.

Purpose of the Study:

  • To evaluate the efficacy of Technetium-99m labeled immunoglobulin G (99mTc-IgG) for localizing abscesses and tumors in animal models.
  • To compare the performance of 99mTc-IgG with 111In-IgG in terms of biodistribution and imaging characteristics.

Main Methods:

  • A one-step labeling method was employed to prepare 99mTc-IgG.
  • The compound was tested in mice, rats, and rabbits with experimentally induced abscesses and tumors.

Related Experiment Videos

  • Blood clearance studies were conducted in dogs.

    • Main Results:

    • While 111In-IgG showed higher absolute concentrations in abscesses and tumors, 99mTc-IgG exhibited a superior abscess-to-tumor ratio.
    • High-quality images were obtained with 99mTc-IgG, enabling abscess detection as early as 30 minutes post-injection.
    • Animal models included turpentine and E. coli abscesses, sarcomas, and gliomas.

    Conclusions:

    • 99mTc-IgG demonstrates significant potential as an effective radiotracer for abscess imaging.
    • Advantages of 99mTc-IgG include simpler preparation, lower cost, greater availability, improved physical properties of 99mTc, and the ability to administer higher doses.
    • 99mTc-IgG offers a promising alternative to 111In-IgG for abscess localization due to its favorable characteristics and imaging performance.