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Contingent negative variation in childhood migraine
E Besken1, R Pothmann, G Sartory
1Department of Clinical Psychology, University of Wuppertal, Germany.
Cephalalgia : an International Journal of Headache
|February 1, 1993
Summary
Children with migraine exhibit a significantly more negative Contingent Negative Variation (CNV) amplitude compared to those with tension-type headaches. This finding suggests potential diagnostic value for CNV in childhood migraine assessment.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Clinical Electrophysiology
Background:
- Adult migraineurs without aura show elevated Contingent Negative Variation (CNV) amplitudes between attacks.
- Diagnosing migraine in children presents challenges, necessitating reliable biomarkers.
Purpose of the Study:
- To investigate Contingent Negative Variation (CNV) in children diagnosed with migraine.
- To explore the diagnostic potential of CNV in pediatric migraine.
Main Methods:
- Ninety-seven children (8-14 years) including migraineurs (n=42), tension-type headache sufferers (n=34), and healthy controls (n=21) were studied.
- CNV was recorded using electroencephalography (EEG) from Fz, Cz, and Pz electrodes with linked earlobes.
- Participants responded to auditory stimuli with a button press, and electrooculography (EOG) monitored eye movements.
Main Results:
- Children with migraine displayed significantly more negative mean CNV amplitudes across all electrode sites compared to tension-type headache patients.
- Migrainous children showed differences from controls primarily at the Cz electrode site.
- A significantly increased mean CNV amplitude and Post-Imperative-Negative-Variation (PINV) was observed in controls compared to the tension headache group.
Conclusions:
- Elevated CNV amplitudes are characteristic of childhood migraine, distinguishing them from tension-type headaches.
- CNV may serve as a valuable electrophysiological marker for diagnosing migraine in pediatric populations.
- Further research is warranted to validate CNV as a diagnostic tool for childhood migraine.