Related Experiment Video
Updated: Aug 17, 2026

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
Published on: April 12, 2018
Collagens in the aged human macular sclera
G E Marshall1, A G Konstas, W R Lee
1Department of Ophthalmology, University of Glasgow, UK.
Abstract:
Scleral tissue from the region of the human macula was studied by the immunogold labeling technique (cryoultramicrotomy and LR white resin embedding) in an attempt to identify the fine structural distribution of collagen types I-VI. Labeling of the striated collagen fibrils suggested colocalisation of collagen types I, III and V with type V occurring at the fibril surface. Both types V and VI collagen were localised to filamentous strands in the interfibrillar matrix. Collagen types II and IV were absent from the scleral stroma.
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