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[Androgen-dependent tumor]
J Shimazaki1, Y Furuya, N Sato
1Department of Urology, School of Medicine, Chiba University.
Nihon Naibunpi Gakkai Zasshi
|January 20, 1993
Abstract:
Androgen receptor is necessary for the proliferation of androgen-dependent tumors including human prostatic cancer and murine androgen-sensitive tumors. However, androgen-independent tumor containing functional androgen receptor was observed in CS 2 cells, which is a subline of androgen-dependent mouse tumor (SC 115). CS 2 showed a new expression of hst-1, the product of which is a family of FGF. CS 2 secreted a growth factor which promotes growth of CS 2 and original SC 115 in an autocrine and paracrine manner. The role of oncogene(s) and suppressor gene(s) on the progression of the tumor is discussed.