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Abnormal glucose tolerance associated with lichen planus

S Halevy, E J Feuerman

    Acta Dermato-Venereologica
    |January 1, 1979
    PubMed
    Summary
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    Lichen planus patients frequently show abnormal glucose tolerance, suggesting a link to carbohydrate metabolism disorders. Over a third of participants exhibited impaired glucose metabolism, highlighting a potential connection.

    Area of Science:

    • Oral Medicine
    • Endocrinology
    • Dermatology

    Background:

    • Lichen planus is an inflammatory condition affecting skin and mucous membranes.
    • Previous research suggests potential links between lichen planus and metabolic disturbances.

    Purpose of the Study:

    • To investigate the prevalence of abnormal oral glucose tolerance in patients diagnosed with lichen planus.
    • To explore the association between lichen planus and carbohydrate metabolism.

    Main Methods:

    • A cohort of 52 patients with lichen planus underwent oral glucose tolerance testing (OGTT).
    • Abnormalities were assessed using an age-related scoring system.
    • Family history of diabetes was also recorded.

    Main Results:

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    • Abnormal oral glucose tolerance was detected in 19 patients (36.5%), with 5 diagnosed with overt diabetes.
    • The most frequent abnormality was elevated blood glucose levels 2 hours post-glucose administration.
    • A family history of diabetes was reported in 14 patients (26.9%).

    Conclusions:

    • The findings support a potential disorder in carbohydrate metabolism associated with lichen planus.
    • Further research is warranted to elucidate the specific mechanisms linking lichen planus and glucose metabolism.