Related Experiment Video
Updated: Aug 3, 2026
07:11
Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
Published on: May 23, 2020
Mandibular primary osteoplasty using orthotopic allografts
N A Plotnikov1, P G Sysoljatin
1Moscow Region M.F. Vladimirsky Research Clinical Institute, Russia.
Summary
This study shows that using lyophilized and formalinized orthotopic allografts for mandibular reconstruction in 680 patients over 30 years yielded good functional and aesthetic results in most cases.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Mandibular defects pose significant challenges in reconstruction.
- Allografts offer a potential solution for restoring mandibular structure and function.
Purpose of the Study:
- To evaluate the long-term efficacy of orthotopic allografts in primary mandibular reconstruction.
- To assess the functional and aesthetic outcomes of this reconstructive approach.
Main Methods:
- Analysis of 30-year clinical data from 680 patients undergoing primary mandibular reconstruction.
- Utilized lyophilized and formalinized orthotopic allografts for defect repair.
Main Results:
- Achieved good or satisfactory outcomes in 573 out of 680 patients (90.2%).
- Unsatisfactory outcomes were reported in 62 patients (9.8%).
- Allografts facilitated the formation of organotypical regenerated bone tissue.
Conclusions:
- Lyophilized and formalinized orthotopic allografts are an optimal material for correcting diverse mandibular defects.
- This method effectively restores mandibular continuity, achieving favorable functional and aesthetic results.
