Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down's syndrome and celiac disease

P Zubillaga1, J C Vitoria, A Arrieta

  • 1Hospital N. S. Aranzazu, San Sebastian, Spain.

Journal of Pediatric Gastroenterology and Nutrition
|February 1, 1993
PubMed
Summary

Individuals with Down's syndrome (DS) have a significantly higher prevalence of celiac disease (CD). Screening for celiac disease markers like IgA anti-gliadin antibodies is recommended for all DS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acral Melanoma in the Caucasian Population: A Comprehensive Cohort Study on Epidemiological, Clinicopathological, and Prognostic Features.

Actas dermo-sifiliograficas·2025
Same author

Acral Melanoma in the Caucasian Population: A Comprehensive Cohort Study on Epidemiological, Clinicopathological, and Prognostic Features.

Actas dermo-sifiliograficas·2025
Same author

[Translated article] RF - Neoadjuvant Therapy in Melanoma.

Actas dermo-sifiliograficas·2023
Same author

RF - Neoadjuvant Therapy in Melanoma.

Actas dermo-sifiliograficas·2022
Same author

Sclerotherapy With Polidocanol for Digital Myxoid Cysts: A Series of 15 Cases.

Actas dermo-sifiliograficas·2021
Same author

Phototherapy for Prurigo Nodularis: Our Experience and a Review of the Literature.

Actas dermo-sifiliograficas·2020

Area of Science:

  • Immunology
  • Genetics
  • Gastroenterology

Background:

  • Down's syndrome (DS) is associated with autoimmune diseases.
  • The link between DS and celiac disease (CD) requires further investigation.

Purpose of the Study:

  • To determine the prevalence of celiac disease in individuals with Down's syndrome.
  • To assess the need for routine celiac disease screening in DS patients.

Main Methods:

  • Studied a random sample of 70 individuals with DS.
  • Measured IgA anti-gliadin antibodies (IgA AGAs) and anti-endomysium antibodies (AEAs).
  • Performed jejunal biopsies and human leukocyte antigen (HLA) typing.

Main Results:

  • 13% of DS individuals had positive IgA AGAs.

Related Experiment Videos

  • 2 out of 8 tested had positive AEAs.
  • 3 out of 8 had flat intestinal mucosa, indicating CD.
  • Calculated a 43% prevalence of CD in the DS cohort.

    • Conclusions:

    • The association between Down's syndrome and celiac disease is significant.
    • Routine screening for celiac disease in DS patients is warranted.
    • Serologic markers like IgA AGA and AEA should be part of DS health assessments.