Effect of prostaglandin F2alpha-THAM in the bitch

The subcutaneous median lethal dosage for prostaglandin F2alpha for the Beagle bitch was determined to be 5.13 mg/kg, using a sequential experimental design. Clinical signs and gross and histologic findings were consistent with a diagnosis of shock syndrome. It was concluded that prostaglandin F2alpha could be used to develop a pharmacologically controlled shock model.