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Corynebacterium group D2 urinary tract infection

R G Stewart¹, V Nowbath, M Carmichael

¹SAIMR Laboratory, Coronation Hospital, Johannesburg.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde

|February 1, 1993

Summary

A multiply resistant Corynebacterium D2 was isolated from a patient's urine in South Africa. This finding highlights the need for effective antibiotic strategies against emerging urinary tract infections.

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Area of Science:

Microbiology
Infectious Diseases
Clinical Medicine

Background:

Urinary tract infections (UTIs) can be caused by various bacteria, including Corynebacterium species.
Antibiotic resistance is a growing global health concern, complicating UTI treatment.
Corynebacterium group D2 is an emerging pathogen implicated in UTIs and alkaline-encrusted cystitis.

Observation:

An unusual, multiply resistant Corynebacterium was isolated from the urine of a comatose patient.
The isolate demonstrated resistance to numerous antibiotics, including beta-lactams, aminoglycosides, and fluoroquinolones.
Susceptibility was noted only to ciprofloxacin, ofloxacin, norfloxacin, vancomycin, and fucidin.

Findings:

The organism was identified as Corynebacterium group D2, marking the first reported isolate in South Africa.

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This case represents a significant challenge due to the extensive antibiotic resistance profile observed.

The patient's clinical presentation and the organism's resistance patterns are detailed.

Implications:

This discovery underscores the importance of antimicrobial susceptibility testing for guiding UTI treatment.
The emergence of resistant Corynebacterium D2 necessitates updated treatment guidelines and surveillance in South Africa.
Further research into the epidemiology and treatment of Corynebacterium D2 UTIs is warranted.