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Möbius syndrome in infant exposed to cocaine in utero
P Kankirawatana1, M B Tennison, O D'Cruz
1Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599-7025.
Pediatric Neurology
|January 1, 1993
Abstract:
The pathophysiology of Möbius syndrome has been debated for decades. A vascular etiology is currently favored because it explains the wide clinical spectrum of this syndrome. An infant is reported who was born with Möbius syndrome after a pregnancy complicated by heavy maternal use of cocaine and alcohol. We speculate that cocaine-induced vasoconstriction at a critical time of cerebrovascular development produced a vascular disruption sequence leading to the Möbius syndrome.