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Pre-eclampsia presenting with deep jaundice

R G Long, P J Scheuer, S Sherlock

    Journal of Clinical Pathology
    |March 1, 1977
    PubMed
    Summary
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    Pre-eclampsia with deep jaundice in a healthy woman was caused by disseminated intravascular coagulation. This condition led to hemolysis and liver cell damage, resulting in jaundice.

    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Hepatology

    Background:

    • Pre-eclampsia is a serious pregnancy complication characterized by high blood pressure.
    • Deep jaundice is a rare but severe manifestation in pre-eclamptic patients.

    Observation:

    • A previously healthy primigravida (first-time pregnant woman) presented with pre-eclampsia complicated by deep jaundice.
    • The primary etiological factor identified was disseminated intravascular coagulation (DIC).

    Findings:

    • Disseminated intravascular coagulation (DIC) induced both hemolytic anemia and hepatocellular necrosis.
    • Liver biopsy revealed fibrin thrombi in capillaries, microhemorrhages, and periportal liver cell loss.
    • Jaundice was attributed to a combination of hemolytic and hepatocellular dysfunction.

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    Implications:

    • This case highlights DIC as a critical factor in severe pre-eclampsia with jaundice.
    • Understanding these mechanisms is vital for timely diagnosis and management of obstetric emergencies.
    • Further research into DIC's role in pre-eclampsia may improve patient outcomes.