Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphonuclear leucocyte function in Behçet's disease

J D Sobel, S Haim, N Obedeanu

    Journal of Clinical Pathology
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intraoperative fentanyl versus paracetamol for ultrasound-guided oocyte retrieval analgesia: a randomised clinical trial.

    International journal of obstetric anesthesia·2025
    Same author

    Lower-body warming and postoperative temperature in cesarean delivery under spinal anesthesia: a randomized controlled trial.

    International journal of obstetric anesthesia·2024
    Same author

    Automated microscopy and pH test for diagnosis of vaginitis - the end of empiricism?

    NPJ digital medicine·2023
    Same author

    Resistance to Fluconazole of Candida albicans in Vaginal Isolates: a 10-Year Study in a Clinical Referral Center.

    Antimicrobial agents and chemotherapy·2023
    Same author

    Efficacy and safety of oral ibrexafungerp for the treatment of acute vulvovaginal candidiasis: a global phase 3, randomised, placebo-controlled superiority study (VANISH 306).

    BJOG : an international journal of obstetrics and gynaecology·2021
    Same author

    Recurrent bacterial vaginosis, relapse or reinfection: the role of sexual transmission.

    BJOG : an international journal of obstetrics and gynaecology·2020
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    Polymorphonuclear leucocyte function in Behçet's disease shows reduced spontaneous migration but increased chemotaxis. This enhanced activity, influenced by serum and intrinsic factors, may contribute to the inflammatory response.

    Area of Science:

    • Immunology
    • Rheumatology
    • Cellular Biology

    Background:

    • Behçet's disease is characterized by a hyperreactive inflammatory response.
    • The precise mechanisms underlying this hyperreactivity, particularly concerning polymorphonuclear leucocyte (PMN) function, require further elucidation.

    Purpose of the Study:

    • To investigate the functional characteristics of polymorphonuclear leucocytes in patients with active Behçet's disease.
    • To identify potential alterations in PMN migration, metabolic activity, and their relationship to serum factors.

    Main Methods:

    • Functional assays were performed on polymorphonuclear leucocytes isolated from 19 patients with active Behçet's disease.
    • Evaluated parameters included spontaneous and stimulated leucocyte migration (chemotaxis), nitroblue tetrazolium (NBT) reduction, and oxygen utilization.

    Related Experiment Videos

  • Incubation of control leucocytes in patient serum was also assessed.

    • Main Results:

    • Significantly reduced spontaneous leucocyte migration was observed in Behçet's disease patients.
    • Stimulated leucocyte chemotactic activity was significantly increased compared to controls.
    • Control leucocytes showed enhanced migration in serum from Behçet's disease patients, indicating the presence of serum factors.
    • Spontaneous nitroblue tetrazrazolium reduction was normal, but stimulated reduction and oxygen utilization were decreased.
    • Enhanced chemotaxis appears to be mediated by both serum and intrinsic leucocyte factors.

    Conclusions:

    • Polymorphonuclear leucocyte chemotactic activity is enhanced in Behçet's disease, driven by both intrinsic leucocyte and serum factors.
    • Minor alterations in leucocyte functional metabolic activity, including reduced stimulated NBT reduction and oxygen utilization, were noted.
    • These PMN functional changes may contribute to the characteristic hyperreactive cellular inflammatory response observed in Behçet's disease.