Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contamination study of multiple-dose vials

P S Melnyk1, Y M Shevchuk, J M Conly

  • 1College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.

The Annals of Pharmacotherapy
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology and impact of methicillin-sensitive <i>Staphylococcus aureus</i> with β-lactam antibiotic inoculum effects in adults with cystic fibrosis.

Antimicrobial agents and chemotherapy·2023
Same author

Robust epidemiological investigations in hospital-based COVID-19 outbreaks cannot be overlooked-even in the era of whole-genome sequencing.

The Journal of hospital infection·2023
Same author

Viral cultures, cycle threshold values and viral load estimation for assessing SARS-CoV-2 infectiousness in haematopoietic stem cell and solid organ transplant patients: a systematic review.

The Journal of hospital infection·2022
Same author

A two-ward acute care hospital outbreak of SARS-CoV-2 delta variant including a point-source outbreak associated with the use of a mobile vital signs cart and sub-optimal doffing of personal protective equipment.

The Journal of hospital infection·2022
Same author

Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis.

The Journal of hospital infection·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same journal

Association Between Prior PARP Inhibitor Maintenance Therapy and Myelosuppression During Subsequent Chemotherapy in Ovarian Cancer.

The Annals of pharmacotherapy·2026
Same journal

Prolonged Response to Nivolumab in Metastatic Vulvar Carcinoma: Should Immunotherapy be Continued and for How Long? A Debatable Issue!

The Annals of pharmacotherapy·2026
Same journal

Stability of Ceftazidime-Avibactam: Changes in Regulatory Information and Implications for Preparation.

The Annals of pharmacotherapy·2026
Same journal

Impact of Early Dose Adjustment of Piperacillin/Tazobactam on Mortality in Critically Ill Patients With Acute Kidney Injury: A Retrospective Multicenter Cohort Study.

The Annals of pharmacotherapy·2026
Same journal

Severe Phototoxic Skin Reaction Associated With Vandetanib: Implications for Pharmaceutical Care.

The Annals of pharmacotherapy·2026
Same journal

Efficacy and Safety of Oral PCSK9 Inhibitors in Adults With Hypercholesterolemia: An Updated Systematic Review and Meta-Analysis of RCTs.

The Annals of pharmacotherapy·2026
See all related articles

Most multiple-dose vials (MDVs) in patient areas were not dated after opening and some were expired. While bacterial contamination was not found, red blood cells were present, highlighting risks of pathogen transmission.

Area of Science:

  • Infection Control
  • Microbiology
  • Patient Safety

Background:

  • Multiple-dose vials (MDVs) are commonly used in healthcare settings.
  • Contamination of MDVs can lead to healthcare-associated infections.
  • Proper handling and storage of MDVs are crucial for patient safety.

Purpose of the Study:

  • To assess the status of opened MDVs in patient care areas.
  • To determine the prevalence of bacterial or cellular contamination in MDVs.
  • To identify potential risks associated with MDV handling and expiration.

Main Methods:

  • A systematic sample of opened MDVs was collected from nursing units.
  • Vials underwent visual inspection for debris and expiration dating.
  • Microbiological cultures and microscopic examinations were performed to detect contamination.

Related Experiment Videos

Main Results:

  • None of the collected MDVs were dated after opening.
  • 4.6% of MDVs were past their manufacturer's expiration date.
  • No bacterial contamination was detected, but one vial contained red blood cells.

Conclusions:

  • Undated and expired MDVs pose a risk for infection transmission.
  • Red blood cell contamination raises concerns about bloodborne pathogen transmission.
  • Recommendations include dating MDVs upon opening, adhering to aseptic techniques, and discarding expired vials.