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Related Experiment Videos

Vertebral bone density in Icelandic women using quantitative computed tomography without an external reference

H Gudmundsdottir1, B Jonsdottir, S Kristinsson

  • 1Department of Internal Medicine, Reykjavík City Hospital, Iceland.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|March 1, 1993
PubMed
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Healthy women experience significant bone loss after menopause, with an accelerated rate in the initial years. Quantitative computed tomography (QCT) using internal references offers a reproducible method for assessing fracture risk.

Area of Science:

  • Bone Densitometry
  • Radiology
  • Gerontology

Background:

  • Vertebral trabecular bone mineral density (BMD) is crucial for assessing skeletal health.
  • Traditional methods for BMD measurement often rely on external references.
  • Understanding age-related bone loss, particularly post-menopause, is vital for osteoporosis management.

Purpose of the Study:

  • To evaluate vertebral trabecular bone mineral density (BMD) in healthy Icelandic women aged 35-64 years.
  • To assess the efficacy of quantitative computed tomography (QCT) using internal references for BMD measurement.
  • To characterize bone loss patterns in relation to menopause.

Main Methods:

  • Quantitative computed tomography (QCT) was employed to measure vertebral trabecular BMD.

Related Experiment Videos

  • Internal references (muscle and subcutaneous fat) were utilized instead of traditional external phantoms.
  • The study included 187 healthy Icelandic women aged 35-64 years.

    • Main Results:

    • A mean annual bone loss of 2.4 mg/cm³ (1.8%) was observed in women aged 35-64 years.
    • An accelerated, exponential phase of bone loss occurred post-menopause, with a 4% annual loss in the first 1-5 years.
    • This initial post-menopausal bone loss was approximately fivefold higher than that in the subsequent 11-15 years after menopause.
    • The reproducibility of the QCT method with internal references was 1.9%.

    Conclusions:

    • Quantitative computed tomography (QCT) using internal references is a highly reproducible method for measuring vertebral trabecular BMD.
    • This technique shows promise for assessing fracture risk in perimenopausal women.
    • QCT with internal references is suitable for monitoring patients with osteoporosis.