Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coordinate activity in retinal and cortical development

L C Katz1

  • 1Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.

Current Opinion in Neurobiology
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb.

Proceedings of the National Academy of Sciences of the United States of America·2010
Same author

Response correlation maps of neurons in the mammalian olfactory bulb.

Neuron·2002
Same author

Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.

Journal of neurophysiology·2001
Same author

Spatial coding of enantiomers in the rat olfactory bulb.

Nature neuroscience·2001
Same author

Symmetry, stereotypy, and topography of odorant representations in mouse olfactory bulbs.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Early development of ocular dominance columns.

Science (New York, N.Y.)·2000
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

New methods reveal how developing brains build neural circuits using spontaneous neuronal activity before sensory input. Gap junctions and chemical synapses coordinate this early activity for circuit formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Neuroscience

Background:

  • Neuronal circuit construction is crucial for brain function.
  • Early brain development relies on intrinsic activity patterns before sensory experience.
  • Both chemical synapses and electrical coupling via gap junctions play roles in neural development.

Purpose of the Study:

  • To explore novel methods for observing and controlling neural activity patterns during brain development.
  • To understand the diverse strategies employed by developing brains to form functional circuits.
  • To investigate the role of spontaneous activity and gap junctions in early circuit formation.

Main Methods:

  • Utilizing advanced techniques for detecting and manipulating neuronal activity.

Related Experiment Videos

  • Analyzing patterns of spontaneous neural firing.
  • Investigating the contribution of gap junction communication.

    • Main Results:

    • Diverse strategies for neural circuit construction have been identified.
    • Spontaneously generated activity provides essential information prior to sensory input.
    • Gap junction coordination is a key mechanism for synchronous activity in early development.

    Conclusions:

    • Spontaneous neuronal activity is a fundamental driver of early neural circuit development.
    • Gap junctions are critical for establishing synchronous activity essential for circuit formation.
    • Understanding these mechanisms offers insights into developmental neuroscience and potential therapeutic targets.