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Temporal variations in iliac trabecular bone formation in vertebral osteoporosis
M E Arlot1, J N Bradbeer, C Edouard
1INSERM U 234, Faculte Alexis Carrel, Universite Claude Bernard, Lyon, France.
Calcified Tissue International
|January 1, 1993
Summary
Bone formation rates in osteoporosis patients can change over time. This study found no systematic changes, suggesting variability in bone remodeling in postmenopausal osteoporosis.
Area of Science:
- Bone biology
- Osteoporosis research
- Histomorphometry
Background:
- Osteoporosis exhibits histologic heterogeneity.
- Controversy exists regarding turnover rate changes in osteoporosis patients over time.
Purpose of the Study:
- To investigate changes in bone formation over time in postmenopausal osteoporosis.
- To determine if bone turnover rates in osteoporosis patients are stable or variable.
Main Methods:
- Dynamic histomorphometry and 85Sr kinetics+calcium balance were used.
- 44 patients were studied over 12 years.
- Two groups were analyzed: short-term (Group 1) and long-term (Group 2) measurements.
Main Results:
- In Group 1, bone formation rate (BFR/BV or BFR/BS) predicted 85Sr measurements (r = 0.66, P < 0.01).
- No significant correlation was found in Group 2, with significantly different regression coefficients (P = 0.01).
- No systematic seasonal or secular changes in bone formation were detected.
Conclusions:
- Bone formation may change over time in postmenopausal osteoporosis.
- Evidence for systematic changes was not found.
- Findings have implications for designing osteoporosis treatment studies.