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Related Experiment Videos

Acquired and developmental brain dysfunction in borderline personality disorder

R van Reekum1

  • 1Department of Psychiatry, McMaster University, Hamilton, Ontario.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|February 1, 1993
PubMed
Summary

Brain dysfunction, including neurological injuries, is examined as a cause of borderline personality disorder (BPD). This review applies causal criteria to assess the evidence linking brain dysfunction to BPD.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Borderline personality disorder (BPD) is a complex mental health condition.
  • The etiology of BPD is multifactorial, with biological and environmental factors implicated.

Purpose of the Study:

  • To critically evaluate the evidence supporting brain dysfunction as a causative factor in borderline personality disorder (BPD).
  • To apply established criteria for causation (e.g., Bradford Hill criteria) to the link between neurological abnormalities and BPD.

Main Methods:

  • Systematic review of existing literature on brain dysfunction and BPD.
  • Application of Bradford Hill criteria (strength, consistency, specificity, temporality, biological gradient, plausibility, experimental verification, analogy) to evaluate causal evidence.

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  • Focus on neurological and neuropsychological evidence, neurobehavioral models, and treatment response.

    • Main Results:

    • Evidence suggests a significant association between brain dysfunction and BPD.
    • Consistency and biological plausibility support a causal link, though specificity and experimental verification remain areas for further research.
    • Neurological and neuropsychological findings correlate with BPD symptomatology.

    Conclusions:

    • Brain dysfunction is a plausible contributing factor to the development of borderline personality disorder (BPD).
    • Further research is needed to solidify causal links and inform clinical assessment and treatment strategies for BPD.
    • This review provides a framework for understanding the neurobiological underpinnings of BPD.